Sunday 25th June 2017,
Continental  Hospitals Blog

‘World Hemophilia Day’ April 17th 2017

On this World Hemophilia Day, let us take the opportunity to come together and support those who are suffering from this inherited bleeding disorder.“Light it up Red”is an initiative to include 40 landmarks around the world lit in RED for the World Hemophilia Day. let’s come together to show our support for the millions who are affected by this bleeding disorder.

What Is Hemophilia?

Hemophilia is a disorder  that leads to excessive bleeding; it is an inherited bleeding disorder. In Hemophilia a person lacks or has low levels of certain proteins called “clotting factors” and the blood doesn’t clot properly. One in every 10,000 people are born with this disease. This rare but serious condition can have life-threatening complications. Since, hemophilia is an inherited genetic condition it is not curable but can be treated to minimize symptoms and prevent future health complications.

Types of Hemophilia:

All the three types are caused by certain deficiency factors.

  • Hemophilia A is the most common type of hemophilia. National Heart, Lung, and Blood Institute (NHLBI), tells, eight out of 10 people with hemophilia have hemophilia A.
  • Hemophilia B, which is also called Christmas disease, is caused by a certain deficiency factor
  • Hemophilia C is a mild form of the disease. People with this rare type of hemophilia often don’t experience spontaneous bleeding. Hemorrhaging typically occurs after trauma or surgery.

Symptoms

The degree of  symptoms depends on the severity of the factor deficiency. Usually, people with mild deficiency may bleed in the case of trauma, some may bleed without reason called as “spontaneous bleeding” In children with hemophilia, these symptoms may occur around age 2.

Spontaneous bleeding can cause the following:

  • Blood in the urine
  • Blood in the stool
  • Deep bruises
  • Large, unexplained bruises
  • Excessive bleeding
  • Bleeding gums
  • Frequent nosebleeds
  • Pain in the joints
  • Tight joints
  • Irritability (in children)

What actually causes Hemophilia?

Normally our body has a process called “the coagulation cascade” which stops bleeding. Blood platelets coagulate, or gather together at the wound site, to form a clot. This is how the body’s clotting factors work together to create a more permanent plug in the wound. A low level of these clotting factors or the absence of them causes bleeding to continue.

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How Is Hemophilia Diagnosed?

All it takes a blood test to diagnose hemophilia. The doctor will take a small sample of blood from your vein and measure the amount of the clotting factor present. The sample is then graded to determine the severity of the factor deficiency:

  • Mild hemophilia is indicated by a clotting factor in the plasma that’s between 5 and 40 percent.
  • Moderate hemophilia is indicated by a clotting factor in the plasma that’s between 1 and 5 percent.
  • Severe hemophilia is indicated by a clotting factor in the plasma of less than 1 percent.

Complications Associated with Hemophilia?

  • Joint damage from repetitive bleeding
  • Deep internal bleeding
  • Neurological symptoms from bleeding within the brain

How is Hemophilia Treated?

Hemophilia A is treated with a prescription hormone. This medication works by stimulating the factors responsible for the process of blood clotting.

Hemophilia B is treated through blood transfusion from a donor with clotting factors. Sometimes, the factors may be given in the synthetic form. These are called “recombinant clotting factors.”

Hemophilia C can be treated by a doctor  using plasma infusion. The infusion works to stop profuse bleeding.

Preventing Hemophilia

Hemophilia cannot be cured, however,  people with hemophilia should take the following precautions:

  • Avoid taking aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).
  • Get vaccinated (including infants) with the hepatitis B vaccine.
  • Avoid circumcising male infants of women known to be carriers until the baby has been tested for hemophilia.
  • Carry information at all times identifying the person as someone with hemophilia.

 

 

 

 

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About The Author

Dr AVS Suresh is a Consultant Medical Oncologist and Haematologist at Continental Cancer and Radiation Center. He is a renowned physician&scientist working on basic and clinical research in haematology/Oncology. After Graduating from IMS, BHU, Varanasi, he worked at AIIMS Delhi. He is an excellent clinician and got some major achievements to his credit including the first Autologous Transplantation in India using GM – CSF, and the first haplo identical transplant in A.P. He has more than 84 publications in international journals; he is a sought after reviewer for various international journals including the American Journal of Clinical Oncology and Leukaemia Research.He has received many awards including the Scholar in Training Award by American association of Cancer research (AACR) 2007; the “Young Oncologist Supportive Award for developing nations” by the European society of Medical Oncology, 2008; and “Department of Science and Technology-Govt of India” award in 2006. He is a Principal Investigator for 62 international clinical trials [including 3 first in human projects] and is theyoungest investigator from India to be audited by US FDA.He got “no action indicated” for the study on Temozolomide, as well as got inspected with minor findings [corrected] by multiple agencies like EMA, BPFK, Malaysia for various molecules. He is a member of various international bodies includingASCO, ESMO, ICON and Ethics committee at MNJ. Dr Suresh is also a Data Safety Monitoring Committee member for Phase I [NCE] trial reviewing DCGI; Steering committee member for ASPECCT [AMGEN project] projects, and also an advisor to the manuscript and medical writing for major pharmaceutical companies. He speaks English, Telugu and Hindi.

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